![]() One hundred and two patients underwent a total of 132 comprehensive iron evaluations between August 2002 and August 2004. Both R2 and R2 * can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques. Combined R2 and R2 * measurements did not yield more accurate results than either alone. Of importance, the R2 calibration curve was similar to the curve generated by other researchers, despite significant differences in technique and instrumentation. 95) for HICs between 1.33 and 32.9 mg/g, but R2 had a curvilinear relationship to HIC. R2 and R2 * correlated closely with HIC (r 2 ≥. In the iron-overloaded group, 22 patients had concurrent liver biopsy. This article compares noninvasive iron estimates using both optimized R2 and R2 * methods in 102 patients with iron overload and 13 controls. The relaxation rates R2 (1/T2) and R2 * (1/T2 *) measured by magnetic resonance imaging (MRI) have different advantages for HIC estimation. The goal of this work was to develop a readily available, noninvasive method for clinical HIC measurement. ![]() Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. ![]()
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